Synthesis of certain substituted psoralenes and related compounds by Robert Carlyle Esse

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  • Psoralens.

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Statementby Robert Carlyle Esse.
The Physical Object
Pagination48 leaves, bound :
Number of Pages48
ID Numbers
Open LibraryOL14300042M

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Synthesis of certain substituted psoralenes and related compounds Public Deposited. Analytics × Add Author: Robert Carlyle Esse. To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request. A series of benzimidazole-derived chalcones containing aromatic amide substituent were designed and synthesized.

All of the chalcone compounds were tested for their in vitro antitumor activity against human cancer cell lines (HCT, HepG2, A, and CRL). The antiproliferative activity of compounds 3, 6, 9, 14, 15, 16 against HCT cells was significantly better than that that of 5 Author: Lintao Wu, Yuting Yang, Zhijun Wang, Xi Wu, Feng Su, Mengyao Li, Xiaobi Jing, Chun Han.

Synthesis of O-substituted benzophenones by Grignard reaction of 3-substituted isocoumarins Article (PDF Available) in Journal of the Chilean Chemical Society 53(3) September with 50 Reads. We report herein the synthesis and biological evaluation of two series of 7-substituted norfloxacin derivatives.

Most compounds tested in this study demonstrated better activity against methicillin-resistant Staphylococcus aureus than norfloxacin. In recent years there has been an extensive variety of syntheses of compounds modeled on C-nucleosides.

6 Three approaches have been primarily used for the synthesis of C-nucleosides: (i) construction of the heterocycle on the preformed carbohydrate, 7 (ii) construction of a sugar moiety onto a preformed heterocycle unit, 8 and (iii) direct coupling of a preformed sugar moiety onto a preformed Cited by: Synthesis of Substituted Iptycenes Synthesis of Substituted Iptycenes Ying-Xian Ma Zheng Meng Chuan-Feng Chen* Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, BeijingP.

of China+86(10) 49 [email protected] We report the single step synthesis of several 3-arylindanes and related compounds via a formal [3+2] cycloaddition. A study of the influence of the aromatic ring substitution pattern Cited by: Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.

Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation. Taking advantage of these results, we developed several novel approaches for the synthesis of pharmaceutically important heterocycles: 1,2-disubstituted benzimidazoles, polysubstituted indoles, N-substituted 1,3-dihydrobenzimidazolones, and substituted 3-acyl by: 2.

Synthesis of N-nitroso-N-substituted glycines V a – c To a suspension of N-substituted glycine IV a–c ( mole) in water ( mL) at 0ºC, a solution of sodium nitrite ( g, mole) in water (24 mL) was added drop wise. After 2 hours, the reaction mixture was filtered and acidified with concentrated hydrochloric by: 6.

The second edition of Comprehensive Organic Synthesis—winner of the PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic themes support effective and efficient synthetic strategies, thus.

Induction of apoptosis is a common chemotherapeutic mechanism to kill cancer cells The thiazole system has been reported over the past decades as a building block for the preparation of anticancer agents.

A novel series of 2-arylalkylaminoamino(3′,4′,5′-trimethoxybenzoyl)-thiazole derivatives designed as dual inhibitors of tubulin and cyclin-dependent kinases (CDKs) were. The expedient synthesis of compounds enriched in sp3 character is key goal in modern drug discovery.

Herein, we report how a single pot Suzuki–Miyaura-hydrogenation can be used to furnish lead and fragment-like products in good to excellent yields. The approach has Cited by: 6.

Related Books SoS C-1 Building Blocks in Organic Synthesis SoS Multicomponent Reactions Cyclopropane motifs are ubiquitous in Nature and are widely employed in pharmaceutically and agrochemically relevant compounds. Scheme 6 Synthesis of cis-heteroaryl-substituted Author: Saher H.

Siddiqui, Chandrasekhar Navuluri, André B. Charette. An approach for the synthesis of E- and Z- trisubstituted alkenes in high stereoisomeric purity is developed by merging catalytic cross-metathesis and cross-coupling by:   The straightforward preparation of benzyl- or in certain cases methyloximinoacetanilides (such as 7a–p,15) and the heating of these intermediates in sulfuric acid, methanesulfonic acid, or, for poorly soluble analogs PPA, has been shown to afford substituted isatins.

This modified aniline-to-isatin route circumvents many of the problems present in the classical Sandmeyer isatin synthesis and allows production of these substituted Cited by: Covering: up to Natural products and their derivatives are used as treatments for numerous diseases.

Many of these compounds are structurally complex, possessing a high percentage of sp 3 hybridized carbons and multiple stereogenic centers. Due to the difficulties associated with the isolation of large numbers of novel natural products, lead discovery efforts over the last two decades Cited by: The article covers the synthesis as well as biological activities of quinoline derivatives such as antimalarial, anticancer, antibacterial, anthelmintic, antiviral, antifungal, anti-inflammatory, analgesic, cardiovascular, central nervous system, hypoglycemic, and miscellaneous : Yamajala B.R.D.

Rajesh. In book: Strategies for Organic Drug Synthesis and Design, Second Edition, pp Three methyl-substituted psoralenes and two methyl-substituted isopsoralenes have been synthesized by a Author: Dan Lednicer. About this book The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry.

Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. • Mannich reaction of indoles to give 3-substituted indoles (gramines) • Modification of Mannich products to give various 3-substituted indoles 1,2 and 1,3-Azoles • Structure and reactivity of 1,2- and 1,3-azoles • Synthesis and reactions of imidazoles, oxazoles and thiazoles • Synthesis and reactions of pyrazoles, isoxazoles and File Size: KB.

Psoralen is the parent compound in a family of naturally occurring organic compounds known as the linear furanocoumarins.

It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone. Psoralen occurs naturally in the seeds of Psoralea corylifolia, as well as in the common fig, celery, parsley, West Indian satinwood, and in all citrus CAS Number: Badd1ley (3,p.

) has reported the synthesis of 9­ substituted purines by the heating of 4-alkylamino-5­ thioformamide compounds above their melting points and Albert (l,p. ) has recently reported the synthee1s of methyl purine by heating 4-methyla.m1no 5-am1nopyr1m1dine with formic acid. It was therefore of interest to us to.

Subsequent reduction or multicomponent reactions of the tetrahydropyrazines gave various piperazine scaffolds, that have a certain value in the synthesis of novel screening compounds with lead-like molecular properties.

James, I. Simpson, J. Grant, V. Sridharan, A. In many books, the definition of the ideal synthesis agrees with several this one-pot methodology for the synthesis of substituted pyrroles from α-diazocarbonyl compounds is a very straightforward route to construct variously substituted compounds of this class starting from readily available : Fernando de C da Silva, Mauricio G Fonseca, Renata de S Rianelli, Anna C Cunha, Maria C B V de Souza.

The reaction of organocerium reagents, generated in situ from aryl and heteroaryl lithium compounds, with cycloalkanones proceeds cleanly to provide alkoxides.

Addition of MsCl or SOCl 2 with DBU gave aryl-substituted cycloalkenes in good yields. A short total synthesis. The solvent properties of DMSO make it a useful media in the synthesis of many agricultural chemicals.

These include some specific nitrophenylether compounds and a range of azole antifungals. These include some specific nitrophenylether compounds and a range of azole antifungals.

General Papers ARKIVOC (xv) hydrate.9 Based on the same principle, we describe here the synthesis of 1,2,4-triazines starting from amides and 1,2-dicarbonyl compounds and hydrazine hydrate in the presence of base.

The novelty of the procedure lies in. SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis.

It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines.Total synthesis of peridinin and related C norcarotenoid butenolides.

Chemis – (). doi: /chem pmid: Cited by: The most frequently encountered synthesis of these compounds (Fig 13) is by N-acylation of anthranilic acid followed by reaction with a substituted aniline under dehydrating conditions (PCl 3, POCl 3, polyphosphoric acid or simply heating the mixture in a microwave).

3 The analogs that have been identified in the illicit drug market are shown. The Synthesis and Chemistry of Certain Anthelmintic Benzimidazoles LB. Townsend and D.S. Wise extensive studies, one health related arena that has benefited greatly has been the treatment ofparasitic diseases. The discovery of In N-substituted benzimi- dazoles, tautomerism is.

If you want to grow the ergot alkaloids that begin the total synthesis of LSD, then you will have to go to the Merck Index and look up the references to the operation. Michael V. Smith's book, Psychedelic Chemistry, has a section on growing Claviceps purpurea, which yield ergot compounds.

Specific microwave effect on Sn- and Ti-MFI zeolite synthesis, Z. Sun et al., RSC Adv.7, Microwave effects in the dilute acid hydrolysis of cellulose to 5-hydroxymethylfurfural, N. Sweygers, et al., Nat. Sci. Rep.8, Synthesis of Highly Uniform Nickel Multipods with Tunable Aspect Ratio by Microwave Power Control,4/5(27).

Following the initial synthesis of phosphaethyne, it was realized that the same compound can be prepared more expeditiously via the flash pyrolysis of methyldichlorophosphine (CH 3 PCl 2), resulting in the loss of two equivalents of hydrogen methodology has been utilized to synthesize numerous substituted phosphaalkynes, including the methyl, vinyl, chloride, and fluoride.

Whereas syntheses targeting an advanced core structure applicable to the synthesis of closely related natural ,34,35 and the related compound synthesis of 3-substituted Cited by: 5,substituted porphyrins are valuable compounds in bioorganic and materials chemistry.

A new synthesis has been developed that employs 1,9-diformylation of a dipyrromethane, conversion of the di Cited by: Recent studies have reported on interesting benzothiophene compounds antitumor properties and we also recently reported on the synthesis, strong antitumor activities and DNA binding features of substituted thieno[3',2':4,5]thieno- and benzo[b]thieno[2,3-c]quinolones, containing different substituents, mostly amidino- or substituted amidino- groups.

including asymmetrical synthesis of N-aryl-substituted allyl amines. This method comprises preparation of selective chiral N-substituted allylic amine compounds from corresponding allylic substrates and substituted hydroxylamines, in the presence of an inexpensive copper-compound and a chiral ligand (US 61/,).

Diagram of the method for. In this book data for characterizing N-substituted porphyrins are summarized. A thorough analysis of the major reactions of these compounds, several unique in porphyrin chemistry, and a critical review of synthetic methods make this book the sole source for laboratory methods in this area available by: Reactions include references to chapters and pages of the following textbooks.

If you wish to limit the reactions to only one of these textbooks, check it specifically. Searchable text includes all words found in reactants, products, conditions, or comments. Shown below are some of the more.Jon D. Rainier Synthesis of Substituted Tetrahydrofurans Matthew A. Perry, Scott D.

Rychnovsky and Nicholas Sizemore Synthesis of Saturated Tetrahydropyrans Kalanidhi Palanichamy and Krishna P. Kaliappan, Synthesis of Saturated Six-Membered Ring Lactones Antonio J.

Moreno-Vargas and Pierre Vogel Synthesis of 7-Oxabicyclo[] heptane and Derivatives M.A. Brimble and L.A. Stubbing Synthesis.

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